TIMI 4

OBJECTIVE: To compare the efficacy of front loaded tPA vs. APSAC vs. the combination of reduced dose tPA and APSAC for treatment of patients presenting within 6 hours of onset of ST elevation myocardial infarction.

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  1. Comparison of front-loaded recombinant tissue-type plasminogen activator, anistreplase and combination thrombolytic therapy for acute myocardial infarction: results of the Thrombolysis in Myocardial Infarction (TIMI) 4 trial. Cannon CP, McCabe CH, Diver DJ, et al. J Am Coll Cardiol 1994;24:1602-10.
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  2. An approach to evaluating thrombolytic therapy in acute myocardial infarction. The 'unsatisfactory outcome' end point. Braunwald E, Cannon CP, McCabe CH. Circulation 1992;86:683-7.
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  3. Noninvasive detection of early coronary artery patency based on plasma MM and MB creatine kinase (CK) isoforms. Abendschein DR , Puleo PR, Cannon CP, and the TIMI IV and V Investigators. Circulation 1992;86(Suppl. I):I-267.
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  4. Does decreasing defect size in serial quantitative planar Tc-99 sestamibi imaging following thrombolytic therapy for acute myocardial infarction correlate with improved left ventricular function? Barr SA, Zaret BL, Cannon CP, Wackers FJT, and the TIMI 4 and 5 Investigators. Circulation 1993;88:I-487.
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  5. Natural history of serial intrahospital quantitative planar Tc-99 sestamibi imaging following thrombolytic therapy for acute myocardial infarction. Wackers FJT, Cannon CP, McMahon M, Zaret BL, and TIMI Investigators. J Am Coll Cardiol 1993;21 (Suppl. A):249A.
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  6. Use of composite endpoints in thrombolysis trials of acute myocardial infarction. Braunwald E, Cannon CP, McCabe CH. Am J Cardiol 1993;72:3G-12G.
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  7. Use of a standardized heparin nomogram to achieve therapeutic anticoagulation after thrombolytic therapy in myocardial infarction. TIMI 4 investigators. Thrombolysis in Myocardial Infarction. Flaker GC, Bartolozzi J, Davis V, McCabe C, Cannon CP. Arch Intern Med 1994;154:1492-6.
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  8. Angiographic predictors of reocclusion after thrombolysis: results from the Thrombolysis in Myocardial Infarction (TIMI) 4 trial. Gibson CM, Cannon CP, Piana RN, et al. J Am Coll Cardiol 1995;25:582-9.
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  9. Previous angina alters in-hospital outcome in TIMI 4. A clinical correlate to preconditioning? Kloner RA, Shook T, Przyklenk K, et al. Circulation 1995;91:37-45.
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  10. How do smokers differ from nonsmokers in their response to thrombolysis? (the TIMI-4 trial). Zahger D, Cercek B, Cannon CP, et al. Am J Cardiol 1995;75:232-6.
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  11. Thrombolytic Therapy for Acute Myocardial Infarction in Patients with Prior Coronary Bypass Surgery: Results from the Thrombolysis in Myocardial Infarction (TIMI) 4 Trial. Zahger D, Cercek B, Cannon CP, Jordan M, Shah PK. J Thromb Thrombolysis 1995;2:45-50.
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  12. Distortion of the terminal portion of the QRS on the admission electrocardiogram in acute myocardial infarction and correlation with infarct size and long-term prognosis (Thrombolysis in Myocardial Infarction 4 Trial). Birnbaum Y, Kloner RA, Sclarovsky S, et al. Am J Cardiol 1996;78:396-403.
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  13. TIMI frame count: a quantitative method of assessing coronary artery flow.Gibson CM, Cannon CP, Daley WL, et al. Circulation 1996;93:879-88.
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  14. Prospective validation of a composite end point in thrombolytic trials of acute myocardial infarction (TIMI 4 and 5). Thrombosis In Myocardial Infarction.Cannon CP, Sharis PJ, Schweiger MJ, et al. Am J Cardiol 1997;80:696-9.
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  15. Rescue angioplasty in the thrombolysis in myocardial infarction (TIMI) 4 trial.Gibson CM, Cannon CP, Greene RM, et al. Am J Cardiol 1997;80:21-6.
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  16. Relation between injections before 90-minute angiography and coronary patency: results of the thrombolysis in myocardial infarction 4 trial. Gibson CM, Marble SJ, Rizzo MJ, et al. Am Heart J 1997;134:351-4.
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  17. Flow after adjunctive and rescue PTCA in TIMI 4 and TIMI 10.Gibson M, McLean C, Rizzo M, Ryan K, Cannon C, Braunwald E, for the TIMI 4 and TIMI 10 A & B Investigators. J Am Coll Cardiol 1997;29 (Suppl. A):131A-132A.
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  18. Protection Conferred by Preinfarct Angina is Manifest in the Aged Heart: Evidence from the TIMI 4 Trial. Kloner RA, Przyklenk K, Shook T, Cannon CP. J Thromb Thrombolysis 1998;6:89-92.
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  19. Earlier time to treatment is associated with improved coronary blood flow in acute MI. Rizzo MJ, Ryan KA, Kelley MB, Moynihan J, Cannon CP, Braunwald E. Circulation 1998:I-698.
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  20. Onset of chest pain between 6PM and 6AM is associated with poorer outcomes following thrombolysis. Rizzo MJ, Ryan KA, Cannon CP, Braunwald E. Circulation 1998;98 (Suppl I):I-764.
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  21. Left coronary artery flow is slower than right coronary artery flow following adjunctive PTCA after thrombolytic administration. Gibson CM, Henry TD, Sequeira R, Schweiger MJ, Frey M, Dodge JT, McKendall G, Giugliano RP,Cannon CP, Antman EM, for the TIMI Study Group. J Am Coll Cardiol 1999;33 (Suppl A):382A.
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  22. Relationship between the presence and duration of chest pain and blood flow at 90 minutes following thrombolytic administration. Ryan KA, Rizzo M, Kelley MB, McCabe CH, Marble SJ, Cannon CP, Gibson CM. J Am Coll Cardiol 1999;33(Suppl A):375A.
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  23. Relationship between TIMI frame count and clinical outcomes after thrombolytic administration. Thrombolysis In Myocardial Infarction (TIMI) Study Group.Gibson CM, Murphy SA, Rizzo MJ, et al. Circulation 1999;99:1945-50.
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  24. Seasonal variation of myocardial infarct size. Kloner RA, Das S, Poole WK, et al. Am J Cardiol 2001;88:1021-4.
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  25. Ischemic preconditioning: implications for the geriatric heart. Kloner RA, Shook T, Cannon CP, Przyklenk K. Am J Geriatr Cardiol 2001;10:145-8; quiz 9-51.
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  26. Comparison of acute myocardial infarct size in patients > or =65 years versus < 65 years in the prethrombolytic period versus the thrombolytic period. Kloner RA, Poole K, Shook T, Przyklenk K, Perritt K, Cannon CP. Am J Cardiol 2002;89:1291-3.
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