TIMI IIIB

OBJECTIVE: To assess the early effects of rtPA vs. placebo and the clinical efficacy of an early invasive vs. conservative strategy in a 2x2 factorial design among patients with unstable angina and non-Q-wave myocardial infarction.

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1. Effects of tissue plasminogen activator and a comparison of early invasive and conservative strategies in unstable angina and non-Q-wave myocardial infarction. Results of the TIMI IIIB Trial. Thrombolysis in Myocardial Ischemia. Circulation 1994;89:1545-56.
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2. Platelet Activation Determined by Flow Cytometry Persists Despite Antithrombotic Therapy in Patients with Unstable Angina and Non-Q-Wave Myocardial Infarction. Becker RC, Bovill EG, Corrao JM, et al. J Thromb Thrombolysis 1994;1:95-100.
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3. Surface 12-Lead Electrocardiographic Findings and Plasma Markers of Thrombin Activity and Generation in Patients with Myocardial Ischemia at Rest. Becker RC, Tracy RP, Bovill EG, et al. J Thromb Thrombolysis 1994;1:101-7.
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4. The clinical use of flow cytometry for assessing platelet activation in acute coronary syndromes. TIMI-III Thrombosis and Anticoagulation Group. Becker RC, Tracy RP, Bovill EG, Mann KG, Ault K. Coron Artery Dis 1994;5:339-45.
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5. Coronary thrombus seen on early angiography in unstable angina/non Q wave MI: TIMI-IIIB results. Anderson HV, Williams DO, Powers E, Cannon CP, Stone P, Sharaf B, Thompson B, Schactman M, Willerson JT, for the TIMI-IIIB Investigators. Circulation 1994;90[Pt. 2]:I-664.
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6. Anticoagulation profile in heparinized patients with unstable angina and non-Q wave myocardial infarction experiencing clinical events.Becker R, Tracy R, Thompson B, Mann K, Bovill E, for the TIMI IIIB Investigators. Circulation 1994;90 [Pt 2]:I-664.
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7. Does pre-treatment with tPA improve safety of coronary angioplasty in acute coronary syndromes? Results from TIMI IIIB.Buller CE, Fung AY, Thompson CR, Ricci DR, Thompson B, Schactman M, Williams DO. Circulation 1994;90[Pt. 2]:I-22.
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8. Should aPTT assays be standardized in multicenter clinical trials designed to investigate the benefits of heparin? Becker R, Tracy R, Bovill E, Thompson B, Randall A, Cannon C, Braunwald E. Should aPTT assays be standardized in multicenter clinical trials designed to investigate the benefits of heparin? J Am Coll Cardiol 1994:57A.
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9. Hadjis T, Lam JYT, Theroux P, Sampalis J, Nasmith J, Randall A, Bovill E, Tracy R, and the TIMI-3 Study Group. Interaction between heparin and nitroglycerin: an ancillary TIMI-III Study. Circulation 1994;90[Pt. 2]:I-374.
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10. One-year results of the Thrombolysis in Myocardial Infarction (TIMI) IIIB clinical trial. A randomized comparison of tissue-type plasminogen activator versus placebo and early invasive versus early conservative strategies in unstable angina and non-Q wave myocardial infarction. Anderson HV, Cannon CP, Stone PH, et al. J Am Coll Cardiol 1995;26:1643-50.
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11. Predictors of non-Q-wave acute myocardial infarction in patients with acute ischemic syndromes: an analysis from the Thrombolysis in Myocardial Ischemia (TIMI) III trials. Cannon CP, Thompson B, McCabe CH, et al. Am J Cardiol 1995;75:977-81.
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12. Cardiac-specific troponin I levels to predict the risk of mortality in patients with acute coronary syndromes. Antman EM, Tanasijevic MJ, Thompson B, et al. N Engl J Med 1996;335:1342-9.
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13. Prognostic value of plasma fibrinogen concentration in patients with unstable angina and non-Q-wave myocardial infarction (TIMI IIIB Trial). Becker RC, Cannon CP, Bovill EG, et al. Am J Cardiol 1996;78:142-7.
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14. Relation between systemic anticoagulation as determined by activated partial thromboplastin time and heparin measurements and in-hospital clinical events in unstable angina and non-Q wave myocardial infarction. Thrombolysis in Myocardial Ischemia III B Investigators. Becker RC, Cannon CP, Tracy RP, et al. Am Heart J 1996;131:421-33.
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15. Results of percutaneous transluminal coronary angioplasty in unstable angina and non-Q-wave myocardial infarction. Observations from the TIMI IIIB Trial. Williams DO, Braunwald E, Thompson B, Sharaf BL, Buller CE, Knatterud GL. Circulation 1996;94:2749-55
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16. Outcome and profile of women and men presenting with acute coronary syndromes: a report from TIMI IIIB. TIMI Investigators. Thrombolysis in Myocardial Infarction. Hochman JS, McCabe CH, Stone PH, et al. J Am Coll Cardiol 1997;30:141-8.
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17. Relevance of increased lung thallium uptake on stress imaging in patients with unstable angina and non-Q wave myocardial infarction: results of the Thrombolysis in Myocardial Infarction (TIMI)-IIIB Study. Jain D, Thompson B, Wackers FJ, Zaret BL. J Am Coll Cardiol 1997;30:421-9.
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18. Fibrinogen, an acute phase protein is not a marker of thrombin- or platelet-mediated prothrombotic potential in unstable angina. Becker RC, Cannon CP, Tracy RP, Bovill E, Spencer F, Burns M, Ball SP, for the TIMI III Investigators. J Am Coll Cardiol 1997;29 (Suppl. A):411A.
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19. The prognostic value of cardiac myosin light chains in acute ischemic sysdromes-results from TIMI 3B. Fung AY, Gawad Y, Thompson CR, Jackowski G, Leitmann R, Antman EM, Tanasijevic MJ, Canner J, Thompson B, Braunwald E. J Am Coll Cardiol 1998;31 (Suppl. A):380A.
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20. Factors associated with failure of medical therapy in patients with unstable angina and non-Q wave myocardial infarction. A TIMI-IIIB database study. Stone PH, Thompson B, Zaret BL, et al. Eur Heart J 1999;20:1084-93.
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21. The role of cardiac troponin-I (cTnI) in risk stratification of patients with unstable coronary artery disease. Tanasijevic MJ, Cannon CP, Antman EM. Clin Cardiol 1999;22:13-6.
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22. Use of risk stratification to identify patients with unstable angina likeliest to benefit from an invasive versus conservative management strategy.Solomon DH, Stone PH, Glynn RJ, et al. J Am Coll Cardiol 2001;38:969-76.
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23. Which patients with unstable angina or non-Q-wave myocardial infarction should have immediate cardiac catheterization? A clinical decision rule for predicting who will fail medical therapy. Solomon DH, Ganz DA, Avorn J, et al. J Clin Epidemiol 2002;55:121-8.
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24. Economic consequences of routine coronary angiography in low- and intermediate-risk patients with unstable angina pectoris. Desai AS, Solomon DH, Stone PH, Avorn J. Am J Cardiol 2003;92:363-7.
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25. Implications of upstream glycoprotein IIb/IIIa inhibition and coronary artery stenting in the invasive management of unstable angina/non-ST-elevation myocardial infarction: a comparison of the Thrombolysis In Myocardial Infarction (TIMI) IIIB trial and the Treat angina with Aggrastat and determine Cost of Therapy with Invasive or Conservative Strategy (TACTICS)-TIMI 18 trial. Sabatine MS, Morrow DA, Giugliano RP, et al. Circulation 2004;109:874-80.
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