Integriti TIMI 20 Trial

Combination reperfusion therapy for acute myocardial infarction with eptifibatide and tenecteplase: design and methodology of the (integrilin tenecteplase for acute myocardial infarction) INTEGRITI trial. Roe MT, Giugliano RP, Harrington RA, Gibson CM, Strony J, Kitt MM, et al. Giugliano RP, Roe MT, Zeymer U, Gibson CM, Fox NL, Greenberg S, Kitt MM, Strony JT, Braunwald E, Heart Drug. 2001; 1: 5-13.
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Effects of facilitated percutaneous coronary intervention on myocardial perfusion and clinical outcome in patients treated with tenecteplase and eptifibatide for acute myocardial infarction. Zeymer U, Van de Werf F, Giugliano RP, Roe MT, Kitt M, Strony JT, Harrington RA, Braunwald E. Eur Heart J. 2002;23 (Suppl):255.
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Combination therapy with eptifibatide and TNK is associated with an improved rate of dye entry into the myocardium (TIMI myocardial frame count) in ST elevation myocardial infarction (STEMI): An INTEGRITI substudy. Gibson CM , Murphy SA, Marble SJ, James D, Kalapanda R, Zeymer U, Kassel K, Giugliano RP. Circulation, 2002; 106(19):II-363.
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Facilitated angioplasty is associated with an improvement in the number of frames required for dye to fill the myocardium (TIMI myocardial frame count) in ST segment elevation myocardial infarction (STEMI). Gibson CM , Murphy SA, James D, Marble SJ, Wong GC, Kalapanda R, Kraimer N, Antman EM. Circulation 2002; 106(19):II-598.
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Impaired TIMI epicardial flow and myocardial perfusion grades are associated with increased time to ST segment recovery in ST segment elevation MI: An INTEGRITI substudy. Gibson CM , Giugliano RP, Roe MT, Murphy SA, Green CL, Sabatine MS, Morrow DA, Schweiger MJ, Miklin JS, Krucoff M. Circulation 2002; 106(19):II-598.
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ST-Segment Recovery with Combination Versus Stand-Alone Thrombolytic Therapy in ST-Segment Elevation Myocardial Infarction is Time-Dependent: Pooled Data from PARADIGM, IMPACT-AMI, GUSTO-V, INTEGRITI. Rebeiz AG, Green CL, Johanson P, Giugliano RP, Harrington RA, Moliterno DJ, Roe MT, Newby LK, Crater SW, Langer A, Krucoff MW.Circulation 2003;108(Suppl IV):378.
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Association between platelet receptor occupancy after eptifibatide (integrilin) therapy and patency, myocardial perfusion, and ST-segment resolution among patients with ST-segment-elevation myocardial infarction: an INTEGRITI (Integrilin and Tenecteplase in Acute Myocardial Infarction) substudy.Gibson CM, Jennings LK, Murphy SA, et al. Circulation 2004;110:679-84.
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Association of the timing of ST-segment resolution with TIMI myocardial perfusion grade in acute myocardial infarction. Gibson CM, Karha J, Giugliano RP, et al. Am Heart J 2004;147:847-52.
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Improved speed and stability of ST-segment recovery with reduced-dose tenecteplase and eptifibatide compared with full-dose tenecteplase for acute ST-segment elevation myocardial infarction. Roe MT, Green CL, Giugliano RP, et al. J Am Coll Cardiol 2004;43:549-56.
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INTEGRITI TIMI 20

OBJECTIVE: To evaluate the safety and efficacy of the combination of eptifibatide and TNK among patients presenting with ST elevation myocardial infarction.