TIMI 4 compared the efficacy of front loaded tPA vs. APSAC vs. the combination of reduced dose tPA and APSAC for treatment of patients presenting within 6 hours of onset of ST elevation myocardial infarction.


Key Study Publications

Cannon, C. P., McCabe, C. H., Diver, D. J., Herson, S., Greene, R. M., Shah, P. K., Sequeira, R. F., Leya, F., Kirshenbaum, J. M., Magorien, R. D., et al., Comparison of front-loaded recombinant tissue-type plasminogen activator, anistreplase and combination thrombolytic therapy for acute myocardial infarction: results of the Thrombolysis in Myocardial Infarction (TIMI) 4 trial J Am Coll Cardiol. 1994;24:1602-10. Abstract