PROVE IT-TIMI 22

PROVE IT-TIMI 22 compared the efficacy of atorvastatin vs. pravastatin and the clinical efficacy of the antibiotic gatifloxacin vs. placebo in a 2 x 2 factorial design among patients presenting with unstable angina or non-Q-wave myocardial infarction.

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Key Study Publications

Cannon CP, Braunwald E, McCabe CH, Rader DJ, Rouleau JL, Belder R, Joyal SV, Hill KA, Pfeffer MA, Skene AM. Intensive versus moderate lipid lowering with statins after acute coronary syndromes. N Engl J Med. 2004;350:1495-504.