Keyword Search Results for "genetic"

O'Connor, F. F., Shields, D. C., Fitzgerald, A., Cannon, C. P., Braunwald, E., Fitzgerald, D. J. Genetic variation in glycoprotein IIb/IIIa (GPIIb/IIIa) as a determinant of the responses to an oral GPIIb/IIIa antagonist in patients with unstable coronary syndromes Blood. 2001;98(12):3256-60. Abstract

Kenny, D., Muckian, C., Fitzgerald, D. J., Cannon, C. P., Shields, D. C. Platelet glycoprotein Ib alpha receptor polymorphisms and recurrent ischaemic events in acute coronary syndrome patients J Thromb Thrombolysis. 2002;13(1):13-9. Abstract

Shields, D. C., Fitzgerald, A. P., O'Neill, P. A., Muckian, C., Kenny, D., Moran, B., Cannon, C. P., Byrne, C. E., Fitzgerald, D. J. The contribution of genetic factors to thrombotic and bleeding outcomes in coronary patients randomised to IIb/IIIa antagonists Pharmacogenomics J. 2002;2(3):182-90. Abstract

Byrne, C. E., Fitzgerald, A., Cannon, C. P., Fitzgerald, D. J., Shields, D. C. Elevated white cell count in acute coronary syndromes: relationship to variants in inflammatory and thrombotic genes BMC Med Genet. 2004;5(NA):13. Abstract

Ranade, K., Kirchgessner, T. G., Iakoubova, O. A., Devlin, J. J., DelMonte, T., Vishnupad, P., Hui, L., Tsuchihashi, Z., Sacks, F. M., Sabatine, M. S., Braunwald, E., White, T. J., Shaw, P. M., Dracopoli, N. C. Evaluation of the paraoxonases as candidate genes for stroke: Gln192Arg polymorphism in the paraoxonase 1 gene is associated with increased risk of stroke Stroke. 2005;36(11):2346-50. Abstract

Iakoubova, O. A., Sabatine, M. S., Rowland, C. M., Tong, C. H., Catanese, J. J., Ranade, K., Simonsen, K. L., Kirchgessner, T. G., Cannon, C. P., Devlin, J. J., Braunwald, E. Polymorphism in KIF6 gene and benefit from statins after acute coronary syndromes: results from the PROVE IT-TIMI 22 study J Am Coll Cardiol. 2008;51(4):449-55.

Iakoubova, O. A., Tong, C. H., Rowland, C. M., Kirchgessner, T. G., Young, B. A., Arellano, A. R., Shiffman, D., Sabatine, M. S., Campos, H., Packard, C. J., Pfeffer, M. A., White, T. J., Braunwald, E., Shepherd, J., Devlin, J. J., Sacks, F. M. Association of the Trp719Arg polymorphism in kinesin-like protein 6 with myocardial infarction and coronary heart disease in 2 prospective trials: the CARE and WOSCOPS trials J Am Coll Cardiol. 2008;51(4):435-43. Abstract

Sabatine, M. S., Ploughman, L., Simonsen, K. L., Iakoubova, O. A., Kirchgessner, T. G., Ranade, K., Tsuchihashi, Z., Zerba, K. E., Long, D. U., Tong, C. H., Packard, C. J., Pfeffer, M. A., Devlin, J. J., Shepherd, J., Campos, H., Sacks, F. M., Braunwald, E. Association between ADAMTS1 matrix metalloproteinase gene variation, coronary heart disease, and benefit of statin therapy Arterioscler Thromb Vasc Biol. 2008;28(3):562-7. Abstract

Mega, J. L., Close, S. L., Wiviott, S. D., Shen, L., Hockett, R. D., Brandt, J. T., Walker, J. R., Antman, E. M., Macias, W. L., Braunwald, E., Sabatine, M. S. Cytochrome P450 genetic polymorphisms and the response to prasugrel: relationship to pharmacokinetic, pharmacodynamic, and clinical outcomes Circulation. 2009;119(19):2553-60. Abstract

Mega, J. L., Close, S. L., Wiviott, S. D., Shen, L., Hockett, R. D., Brandt, J. T., Walker, J. R., Antman, E. M., Macias, W., Braunwald, E., Sabatine, M. S. Cytochrome p-450 polymorphisms and response to clopidogrel New England journal of medicine. 2009;360(4):354-62. Abstract

Mega, J. L., Morrow, D. A., Brown, A., Cannon, C. P., Sabatine, M. S. Identification of genetic variants associated with response to statin therapy Arteriosclerosis, thrombosis, and vascular biology. 2009;29(9):1310-5. Abstract

Storey, R. F., Melissa Thornton, S., Lawrance, R., Husted, S., Wickens, M., Emanuelsson, H., Cannon, C. P., Heptinstall, S., Armstrong, M. Ticagrelor yields consistent dose-dependent inhibition of ADP-induced platelet aggregation in patients with atherosclerotic disease regardless of genotypic variations in P2RY12, P2RY1, and ITGB3 Platelets. 2009;20(5):341-8. Abstract

Maree, A. O., Vangjeli, C., Jneid, H., Ryan, J., Cox, D., Cannon, C. P., Shields, D. C., Fitzgerald, D. J. G-protein beta3 subunit polymorphism and bleeding in the orbofiban in patients with unstable coronary syndromes-thrombolysis in myocardial infarction 16 trial J Thromb Haemost. 2010;8(5):934-41. Abstract

Mega, J. L., Close, S. L., Wiviott, S. D., Shen, L., Walker, J. R., Simon, T., Antman, E. M., Braunwald, E., Sabatine, M. S. Genetic variants in ABCB1 and CYP2C19 and cardiovascular outcomes after treatment with clopidogrel and prasugrel in the TRITON-TIMI 38 trial: a pharmacogenetic analysis Lancet. 2010;376(9749):1312-9. Abstract

Shiffman, D., Sabatine, M. S., Louie, J. Z., Kirchgessner, T. G., Iakoubova, O. A., Campos, H., Devlin, J. J., Sacks, F. M. Effect of pravastatin therapy on coronary events in carriers of the KIF6 719Arg allele from the cholesterol and recurrent events trial Am J Cardiol. 2010;105(9):1300-5. Abstract

Li, Y., Sabatine, M. S., Tong, C. H., Ford, I., Kirchgessner, T. G., Packard, C. J., Robertson, M., Rowland, C. M., Bare, L. A., Shepherd, J., Devlin, J. J., Iakoubova, O. A. Genetic variants in the KIF6 region and coronary event reduction from statin therapy Hum Genet. 2011;129(1):17-23. Abstract

Mega JL, Hochholzer W, Frelinger AL 3rd, Kluk MJ, Angiolillo DJ, Kereiakes DJ, Isserman S, Rogers WJ, Ruff CT, Contant C, Pencina MJ, Scirica BM, Longtine JA, Michelson AD, Sabatine MS. Dosing clopidogrel based on CYP2C19 genotype and the effect on platelet reactivity in patients with stable cardiovascular disease. J Am Med Assoc. 2011;306:2221-8. Abstract

Mega, J. L., Hochholzer, W., Frelinger, A. L., Kluk, M. J., Isserman, S., Rogers, W. J., Angiolillo, D. J., Kereiakes, D. J., Ruff, C. T., Berg, D. D., Cyr, J., Scirica, B. M., Grip, L., Mesa, R. A., Mattimore, J. F., Longtine, J. A., Michelson, A. D., Sabatine, M. S. ELEVATE-TIMI 56: Escalating Clopidogrel by Involving a Genetic Strategy-TIMI 56 Circulation. 2011;124(21):2371-2372. Abstract

Mega, Jessica L, Close, Sandra L, Wiviott, Stephen D, Man, Michael, Duvvuru, Suman, Walker, Joseph, Sundseth, Scott S, Macias, William L, Antman, Elliott M, Braunwald, Eugene, Sabatine, Marc S Abstract 11255: PON1 Q192R (rs662) Genetic Variant and Response to Clopidogrel and Prasugrel Circulation. 2011;124(21 Supplement):A11255.

Carreras, Edward T, Hochholzer, Willibald, Frelinger, Andrew L, Hoffman, Elaine B, O'Donoghue, Michelle L, Wiviott, Stephen D, Angiolillo, Dominick J, Michelson, Alan D, Sabatine, Marc S, Mega, Jessica L Abstract 12325: Diabetes Mellitus, CYP2C19 Genotype, and Pharmacodynamic Response to Clopidogrel Dosing: Insights From the ELEVATE-TIMI 56 Trial Circulation. 2013;128(22 Supplement):A12325.

Desai, N. Variability in Response: Patterns in Prescribming Antiplatelet Therapy after CYP2C19 Genotyping among Patients with ACS and PCI Journal of the American College of Cardiology. 2013;61(10):A39.

Scott, S. A., Sangkuhl, K., Stein, C. M., Hulot, J. S., Mega, J. L., Roden, D. M., Klein, T. E., Sabatine, M. S., Johnson, J. A., Shuldiner, A. R. Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for cytochrome P450-2C19 (CYP2C19) genotype and clopidogrel therapy: 2013 Update Clin Pharmacol Ther. 2013;NA(NA):NA.

Mega, J. L., Giugliano, R. P. Genotype-Guided Dosing of Warfarin Clin Chem. 2014;NA(NA):NA.