EXTRACT TIMI 25

OBJECTIVE: To evaluate the efficacy and safety of enoxaparin throughout the index hospitalization or unfractionated heparin for at least 48 hours in patients with ST-elevation myocardial infarction scheduled to undergo fibrinolysis.

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1. Enoxaparin versus unfractionated heparin as antithrombin therapy in patients receiving fibrinolysis for ST-elevation myocardial infarction. Design and rationale for the Enoxaparin and Thrombolysis Reperfusion for Acute Myocardial Infarction Treatment-Thrombolysis In Myocardial Infarction study 25 (ExTRACT-TIMI 25). Antman EM, Morrow DA, McCabe CH, et al. Am Heart J 2005;149:217-26.
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2. Enoxaparin versus unfractionated heparin with fibrinolysis for ST-elevation myocardial infarction. Antman EM, Morrow DA, McCabe CH, et al. N Engl J Med 2006;354:1477-88.
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3. Evaluation of the TIMI risk index in a multi-continental population of 19,103 patients with STEMI in the ExTRACT-TIMI 25 trial. Morrow DA, Wiviott SD, Sabatine MS, Giugliano RP, McCabe CH, Antman EM, Braunwald E. J Am Coll Cardiol 2006;47:223A.
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4. Enoxaparin vs. unfractionated heparin with fibrinolysis for ST-elevation myocardial infarction in elderly and younger patients: results from ExTRACT-TIMI 25. White HD, Braunwald E, Murphy SA, et al. Eur Heart J 2007;28:1066-71.
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5. Efficacy and safety of enoxaparin versus unfractionated heparin in patients with ST-segment elevation myocardial infarction also treated with clopidogrel.Sabatine MS, Morrow DA, Dalby A, et al. J Am Coll Cardiol 2007;49:2256-63.
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6. The impact of renal dysfunction on outcomes in the ExTRACT-TIMI 25 trial.Fox KA, Antman EM, Montalescot G, et al. J Am Coll Cardiol 2007;49:2249-55.
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7. Outcomes and optimal antithrombotic therapy in women undergoing fibrinolysis for ST-elevation myocardial infarction. Mega JL, Morrow DA, Ostor E, et al. Circulation 2007;115:2822-8.
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8. Percutaneous coronary intervention in patients receiving enoxaparin or unfractionated heparin after fibrinolytic therapy for ST-segment elevation myocardial infarction in the ExTRACT-TIMI 25 trial. Gibson CM, Murphy SA, Montalescot G, et al. J Am Coll Cardiol 2007;49:2238-46.
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9. Enoxaparin is superior to unfractionated heparin in patients with ST elevation myocardial infarction undergoing fibrinolysis regardless of the choice of lytic: an ExTRACT-TIMI 25 analysis. Giraldez RR, Nicolau JC, Corbalan R, et al. Eur Heart J 2007;28:1566-73.
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10. Global outcomes of ST-elevation myocardial infarction: comparisons of the Enoxaparin and Thrombolysis Reperfusion for Acute Myocardial Infarction Treatment-Thrombolysis In Myocardial Infarction study 25 (ExTRACT-TIMI 25) registry and trial. Steinberg BA, Moghbeli N, Buros J, et al. Am Heart J 2007;154:54-61.
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11. A strategy of using enoxaparin as adjunctive antithrombin therapy reduces death and recurrent myocardial infarction in patients who achieve early ST-segment resolution after fibrinolytic therapy: the ExTRACT-TIMI 25 ECG study. Scirica BM, Morrow DA, Sadowski Z, et al. Eur Heart J 2007;28:2070-6.
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12. TIMI risk index and the benefit of enoxaparin in patients with ST-elevation myocardial infarction. Ruff CT, Wiviott SD, Morrow DA, et al. Am J Med 2007;120:993-8.
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13. Effect of enoxaparin versus unfractionated heparin in diabetic patients with ST-elevation myocardial infarction in the Enoxaparin and Thrombolysis Reperfusion for Acute Myocardial Infarction Treatment-Thrombolysis In Myocardial Infarction study 25 (ExTRACT-TIMI 25) trial. Morrow DA, Antman EM, Murphy SA, et al. Am Heart J 2007;154:1078-84, 84 e1.
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14. Association of non-steroidal anti-inflammatory drugs with outcomes in patients with ST-segment elevation myocardial infarction treated with fibrinolytic therapy: an ExTRACT-TIMI 25 analysis. Gibson CM, Pride YB, Aylward PE, Col JJ, Goodman SG, Gulba D, Bergovec M, Kunadian V, Zorkun C, Buros JL, Murphy SA, Antman EM. J Thromb Thrombolysis: in press.
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