ENTIRE TIMI 23

OBJECTIVE: To assess the safety and efficacy of enoxaparin as an adjunct to thrombolysis with or without GP IIb/IIIa therapy among patients presenting with ST elevation myocardial infarction.

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1. A strategy of using enoxaparin as adjunctive antithrombin therapy reduces death and recurrent myocardial infarction in patients who achieve early ST-segment resolution after fibrinolytic therapy: the ExTRACT-TIMI 25 ECG study. Scirica BM, Morrow DA, Sadowski Z, et al. Eur Heart J 2007;28:2070-6.
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2. Enoxaparin attenuates the rise in von willebrand factor after fibrinolysis for ST-elevation myocardial infarction: Results from ENTIRE-TIMI 23.Morrow DA , Rifai N, Bassand JP, Bigonzi F, Pisaipia G, Van de Werf F, Antman EM. Eur Heart J 2002; Supp I.
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3. Enoxaparin attenuates the rise in Von Willebrand factor in patients with ST-segment elevation mycoardial infarction treated with fibrionlysis: results from ENTIRE-TIMI 23.Morrow DA, Rifai N, Bigonzi F, Bassand JP, Pisapia G, Hecquet C, Van de Werf F, Antman EM. Eur Heart J. 2002;23 (Abstr suppl):506.
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4. B-type natriuretic peptide at presentation and prognosis in patients with ST-segment elevation myocardial infarction: an ENTIRE-TIMI-23 substudy. Mega JL, Morrow DA, De Lemos JA, et al. J Am Coll Cardiol 2004;44:335-9.
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5. Increased platelet receptor occupancy following eptifibatide therapy is associated with improved patency, tissue level perfusion and ST segment resolution in ST segment elevation myocardial infarction: An INTEGRITI substudy. Gibson CM, Jennings LK, Lorenz D, Giugliano RP, Harrington RA, Roe MT, Murphy SA, Cholera S, Baran KW, Hobbach H, Braunwald E.Circulation 2004;110(6):679-84
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6. Angiographic perfusion score: an angiographic variable that integrates both epicardial and tissue level perfusion before and after facilitated percutaneous coronary intervention in acute myocardial infarction. Gibson CM, Murphy SA, Morrow DA, et al. Am Heart J 2004;148:336-40.
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7. Serum levels of the interleukin-1 receptor family member ST2 predict mortality and clinical outcome in acute myocardial infarction. Shimpo M, Morrow DA, Weinberg EO, et al. Circulation 2004;109:2186-90.
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8. Stratification in STEMI with multiple biomarkers. Gelfand EV, Morrow DA, Sabatine MS, Rifai N, Murphy SA, McCabe CH, Antman EM. Risk J Am Coll Cardiol 2004;4 43(5):259A.
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9. Changes in soluble markers of endothelial function correlate with TIMI flow grade and corrected TIMI frame count after fibrinolysis. An ENTIRE TIMI 23 substudy. Ray KK, Morrow D, Murphy S, McCabe C, Antman E, Braunwald E, Gibson CM.Circulation 2004;110:III-660.
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10. Predictors of the rise in vWF after ST elevation myocardial infarction: implications for treatment strategies and clinical outcome: An ENTIRE-TIMI 23 substudy.Ray KK, Morrow DA, Gibson CM, Murphy S, Antman EM, Braunwald E. Eur Heart J 2005;26:440-6.
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